Technical References
Posters
Reproducible Planar Organoids for the Study of AD-Associated Neuroinflammation
Presented at: SfN 2025
Bridging the Gap: a complex, reproducible, multicellular, glia-containing cerebral organoid system for the study of neuroinflammation in pre-clinical screening and beyond
Presented at: SfN 2024
Synthetic substrates enhance adherence, neural activity, and network development of in vitro neural cultures
Presented at: SfN 2024 in collaboration with Axion Biosystems
Assessment of microglial activity in an induced pluripotent stem-cell derived neural organoid on synthetic hydrogels to study neuroinflammation
Presented at: ISSCR 2023
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Modeling neuroinflammation induced by AB oligomers in cultured human iPSC-derived neural organoids on synthetic hydrogels
Presented at: SfN 2022
Modeling Neuroinflammation with iPSC-derived microglia cultured on Synthetic Hydrogels
Presented at: SfN 2022
Advanced synthetic biomaterials that enable microphysiological systems
Presented at: MPS World Summit 2022
Induced Pluripotent Stem Cell-Derived Neural Organoids Incorporating Microglia of interrogation of Neural Inflammation
Presented at: ISSCR 2022
Chemically defined substrates in a ready-to-use format that promote differentiation, accelerated maturation and neurite extension of multiple neuronal subtypes for screening applications
Presented at: ISSCR 2022
Induced Pluripotent Stem Cell-Derived Neural Organoids Generated on Synthetic Hydrogels for Interrogation of Neural Inflammation and Toxicity
Presented at: ISSCR 2021, SfN 2021
Chemically defined substrates in a ready to use format that promote differentiation, accelerated maturation and neurite extension of multiple neuronal subtypes for screening applications
Presented at: ISSCR 2021, SfN 2021
DAMP-mediated Neuroinflammation in Neuroimmune Organoids for Drug Discovery
Presented at: SfN 2025
Neural organoids incorporating microglia for interrogation of neural toxicity
Presented at: SfN 2024
Chemically defined substrates in a ready-to-use format that promote adhesion, neurite extension and long-term cultures for multiple induced pluripotent-derived neural subtypes
Presented at: ISSCR 2023
Validation of a screening platform for vascular toxicities utilizing synthetic substrates
Presented at: SOT 2019
Publications
Neural Organoids
E. Aisenbrey & W.L. Murphy. Nature Reviews Materials, 2020. Synthetic alternatives to Matrigel
G. Kaushik, et al. Advanced Healthcare Materials, 2018. Quantitative label-free imaging of three-dimensional vascular networks self-assembled in synthetic hydrogels
E.H. Nguyen & W.L. Murphy. Biomaterials, 2018. Customizable biomaterials as tools for advanced anti-angiogenic drug discovery
C. Barry, et al. Exp Biol Med (Maywood). 2017. Uniform neural tissue models produced on synthetic hydrogels using standard culture techniques
M.P. Schwartz, et al. Experimental Biology and Medicine, 2017. Uniform neural tissue models produced on synthetic hydrogels using standard culture techniques
E.H. Nguyen, et al. Nature Biomedical Engineering, 2017. Versatile synthetic alternatives to Matrigel for vascular toxicity screening and stem cell expansion
D.G. Belair, et al. Acta Biomaterialia. 2016. Human iPSC-derived endothelial cell sprouting assay in synthetic hydrogel arrays
S. Pellett, et al. Scientific Reports, 2015. Human induced pluripotent stem cell derived neuronal cells cultured on chemically-defined hydrogels for sensitive in vitro detection of botulinum neurotoxin
Synthetic Substrates
J.M. Shireman, et al. Journal of Neuro-Oncology, 2026. Human neural organoid modeling of diffuse midline glioma captures the complexity of patient tumors
N.Y. Yuan, et al. Current Research in Toxicology, 2025. Neural organoids incorporating microglia to assess neuroinflammation and toxicities induced by known developmental neurotoxins
C. Seah, et al., Stroke, 2025. Single-Cell sequencing of human neural organoids in a model of intracerebral hemorrhage reveals temporally dynamic responses to blood
J. Majumder, et al. Journal of Tissue Engineering, 2024. Human induced pluripotent stem cell-derived planar neural organoids assembled on synthetic hydrogels
S.G. Mina, et al. Frontiers in Big Data, 2019. Assessment of drug-induced toxicity biomarkers in the brain microphysiological system (MPS) using targeted and untargeted molecular profiling
E.H. Nguyen, et al. Applied In Vitro Toxicology, 2019. Neurovascular organotypic culture models using induced pluripotent stem cells to assess adverse chemical exposure outcomes
Iwata Y, et al. Assay Drug Dev Technol. 2017. High-content assay multiplexing for vascular toxicity screening in induced pluripotent stem cell-derived endothelial cells and human umbilical vein endothelial cells
M.P. Schwartz, et al. Proceedings of the National Academy of Sciences, 2015. Human pluripotent stem cell-derived neural constructs for predictive neurotoxicity
Z. Hou, et al. Stem Cell Research and Therapy, 2013. A human pluripotent stem cell platform for assessing developmental neural toxicity screening
Media and Press Releases
2/3/26 - Press release - Stem Pharm Partner InMed Pharmaceuticals Positive Data from Human Brain Organoid Neuroinflammation Models Supporting the INM-901 Alzheimer's Disease Program - read
2/3/26 - Press release - Stem Pharm Announced as an Awardee of the Innovation to Commercialization Pipeline (ICP) program - read
6/27/25 - Open Record Podcast w/CEO Steve Visuri - listen
6/18/25 - FOX6 News Milwaukee Feature Video and Story - watch/read, watch
9/24/24 - Press release - Stem Pharm Awarded NIH SBIR Grant to Advance Temporal Lobe Epilepsy Neuroinflammation Research - read
8/26/25 - StartUp Health Transformer Journal - Stem Pharm is Revolutionizing Drug Discovery for Brain Diseases - read
5/22/24 - Stem Pharm among First Companies to Join StartUp Health Alzheimer’s Moonshot - read
3/19/24 - Science Magazine webinar by COO and co-founder Connie Lebakken “It’s Personal: Organoids leading the charge in precision medicine” - watch
10/10/23 - Press release - Stem Pharm and Verge Genomics Form Collaboration Focused on Parkinson’s Disease - read
9/21/23 - Press release - Stem Pharm Awarded NIH SBIR Grant to Advance Alzheimer’s Disease Neuroinflammation Research - read
8/10/23 - Press release - Stem Pharm Awarded STTR Grant from National Cancer Institute for Advanced Glioblastoma Research - read
12/20/22 - Press release - Stem Pharm Joins Merck Digital Sciences Studio Accelerator Program to Drive Innovations in Neurological Drug Discovery - read
10/13/22 - Stem Pharm receives 2022 Wisconsin Innovation Award - read
10/21/19 - Illumina Accelerator turns five and backs five new startups - read
2/6/19 - Stem Pharm featured on Big Ten Network video - watch